Here are some fast facts clinicians should be aware of regarding Kcentra: Kcentra is marketed in over 25 countries around the world by CSL Behring as Beriplex® or Confidex®. It is four-factor PCC, containing factors II, VII, IX, and X, in varying amounts, based on the size of the vial. It also contains Proteins C and S as well as heparin and antithrombin III. The table below provides a breakdown of the contents per 500 [...]

In the coming weeks we will live update how we will incorporate the new 4-factor PCC products into our institutional formulary and practice.Exciting developments to come!

Drug shortages continue to wreak havoc on health care in US hospitals.  It seems every day there is yet another drug, more critical to medicine than the last, that’s unavailable due to shortages. Over the past few weeks, nimodipine has been going, going, gone.  Now reaching for alternatives, in this case, is proving difficult as a result of limited data on alternatives leaving many in a troubling situation.  Nicardipine, diltiazem, magnesium and other investigational agents [...]

We all know that the effects produced from the toxic ingestion of cocaine and alcohol as separate entities are excessive stimulation and pronounced depression, respectively. So what are the effects of the toxic ingestion of both compounds together? Enter cocaethylene...and it is far from the Coca-Cola produced during your great grandmother's time. Cocaethylene (also known as ethylbenzoylecgonine) is produced from the concomitant ingestion of cocaine and alcohol. It is formed by the liver through a [...]

Originating in anesthesia, promoted in emergency medicine by EMCrit.org and EMRAP, the utilization of push dose pressors has been growing. While there doesn’t exist much data to back up its use, I think the clinical experience speaks for itself.  In my experience has been generally good with recommending push dose phenylephrine aka. “Neostick,” if the dose is appropriate (80-100 mcg, not 20mcg) and the timing is appropriate (not after hours of hypotension).  Likewise, expectations of [...]

A patient is wheeled into your trauma bay after a nasty head-on collision on a major highway. According to the paramedics, the downtime and length of anoxia in the patient is unknown, and because of this, the patient is intubated. Vital signs are unobtainable, and pulses are lost on the scene. The patient is now in pulseless electrical activity (PEA), and cardiopulmonary resuscitation is initiated. The decision is made to perform an emergent thoracotomy. The [...]

A patient is wheeled into your trauma bay after a nasty head-on collision on a major highway. According to the paramedics, the downtime and length of anoxia in the patient is unknown, and because of this, the patient is intubated. Vital signs are unobtainable, and pulses are lost on the scene. The patient is now in pulseless electrical activity (PEA), and cardiopulmonary resuscitation is initiated. The decision is made to perform an emergent thoracotomy. The [...]

Very little of what we do on a daily basis, as pharmacists, fit into discrete silos.  In contrast to our didactic education (or mine, at least), chapters are studied focusing on specific disease states, medication classes are analyzed individually and cases are discussed with rarely more than one problem.  Of course learning to walk before you run through study and comprehension of the basic components and methods of problem solving is critical. However, it leaves [...]

Let us say that you have a patient who presents with cardiac arrest with a rhythm of pulseless electrical activity. After going through a mental checklist of the 6Hs and 6Ts, you are highly suspicious that the patient has experienced a pulmonary embolism, and the decision is made to administer alteplase. You are informed that the rectal temperature of the patient is 32°C.  An interesting question can be posed from this situation. What bearing do [...]

While in pharmacy school, I was fortunate enough to have an athletic scholarship. Balancing the responsibility to workout before and after class four days per week, compete on the weekend and study in-between was certainly challenging. But being a pharmacy student-athlete, I found, to be more interesting and though provoking by marrying the two together: pharmacy and athletics - drug/supplements and performance.Most athletes competing at a high level are focused on improving themselves, through both [...]