Liberal Changes to rt-PA Contraindications for Acute Ischemic Stroke
Flying in under the radar recently were the changes to the Alteplase (rt-PA) prescribing information. These changes pertain to the contraindications to use of the drug in acute ischemic stroke. It's hard to find anything on the particulars about why the FDA authorized such changes, and more puzzlingly, why.The updated contraindications now read as follows: LinkDo not administer Activase to treat acute ischemic stroke in the following situations in which the risk of bleeding is [...]