I recently had the opportunity of recording a podcast episode for the Virtual Critical Care Rounds (VCCR) of the Society of Critical Care Medicine (SCCM) with Sean Kane, PharmD, BCPS (@ClinCalc). We discussed the nuances of acetaminophen toxicity and practical application of the Rumack-Matthew nomogram in the clinical setting. You can find the link to the podcast episode here (as well as other episodes of the SCCM VCCR). Some suggested references for the episode are [...]

IntroductionNausea and vomiting is a common ailment in pregnancy affecting approximately 70 to 80% of all pregnant women. (1) Ondansetron, a 5-HT3 receptor antagonist, is commonly used to treat nausea and vomiting of varying etiologies including hyperemesis gravidarum. (2) Recently the safety of ondansetron in pregnancy has been called into question. Concern for fetal abnormalities, including cardiac malformations and cleft palates caused by ondansetron have been raised, leading to a petition to the Food and [...]

I had the chance to talk with Sean P. Kane, PharmD, BCPS about angiotensin-converting enzyme (ACE) inhibitor-induced angioedema. And it was recorded!As part of the SCCM VCCR podcast, this episode we spoke about a variety of treatment approaches for ACE inhibitor-induced angioedema are discussed, including fresh frozen plasma, ecallantide, icatibant, and conventional therapies for undifferentiated angioedema. Here is the link, and some show notes to go along with it.Compared to a type 1 IGE mediated [...]