L-carnitine and the Nike Oregon Project
What do a 45 mL infusion, L-carnitine and Androgel have in common?
Diphacinone Toxicity
Daniel Hu, PharmD, BCCCP Critical Care and Emergency Medicine Pharmacist Providence St. Peter Hospital Diphacinone (2-diphenylacetyl-1,3-indanedione, CAS Number 82-66-6) is an indandione-type anticoagulant.1,2 It falls into a class of compounds known as long-acting anticoagulant rodenticides, along with brodifacoum, bromadiolone, chlorophacinone, and difenacoum, which inhibit the synthesis of clotting factors II, VII, IX, and X. These compounds were developed to replace warfarin in rodenticides and many available mouse and rat baits today contain these superwarfarins.1 Diphacinone [...]
Is Thiamine IV Push Safe?
Thiamine IV push? @raviempharmD (Ravipal Singh, PharmD, BCCCP) dives deep to answer this question
The Cure For Burnout Starts Here
The cure for burnout is simple, and starts with one simple step
The 5 Types of Interviewees: Reflections of a PGY-1 Resident
Next in the High-Yield MED Reviews giveaway: The 5 Types of Interviewees: Reflections of a PGY-1 Resident
Antidote For Isoniazid-Induced Seizures
First entry in the High-Yield MED Reviews BCCCP give away - Antidote For Isoniazid-Induced Seizures.
DVT / PE
The coagulation cascade, at least the way I learned it in pharmacy school, needs to be burned. The next time you’re looking at an adaptation of this pathway, point out the platelet. If you can’t, don’t continue to read that source. 66 year old male being discharged from the ED with diagnosis of DVT. Will be started on oral anticoagulation, and followed in clinic. Which DOAC is preferred and should there be any bridge with [...]
Free Book Giveaway
The friendly folks at High-Yield MED Reviews were gracious enough to provide 20 free copies of two of my new eBooks. To get your FREE eBook, email me at iempharmd@gmail.com. But do it fast before all 20 are gone!
Cannabinoid Hyperemesis Syndrome (CHS): Getting “Into the Weeds” on a Complication of Chronic Marijuana Use
Guest post by Evan Mulvihill, PharmD on the hot topic of Cannabinoid Hyperemesis Syndrome
Pit Viper Antivenoms
A discussion of antivenom for pit viper envenomations.
Single Dose Aminoglycoside For Urinary Tract Infections
Looking for a single dose, no compliance issues, inexpensive, safe, and effective option to treat urinary tract infections? An older therapeutic option might be the answer. A recent systematic review by Goodlet et al. looks into the utility of single dose aminoglycosides (AGs) to treat cysitis.1 Article A Systematic Review of Single-Dose Aminoglycoside Therapy for Urinary Tract Infection: Is It Time To Resurrect an Old Strategy?Kellie J. Goodlet, PharmD , Fatima Z. Benhalima, and Michael [...]
Atrial Fibrillation
Atrial fibrillation - the old debate of rate versus rhythm rages on but there are fundamental aspects that all EM pharmacists must know. - Art credit: "Autumn Rhythm" Jackson Pollock
I Have Andexanet Issues, 2: A Formulary Toolkit
Zahra Nasrazadani, PharmD, BCPS Emergency Medicine Clinical Pharmacist Salina Regional Health Center A few months ago, Kristina Kipp wrote her inaugural EMCrit article enumerating her (extremely justified) concerns with the data we had available at the time regarding andexanet alfa…or should I say “coagulation factor Xa (recombinant), inactivated-zhzo”(1)? Since then—and in a somewhat perverse order of operations—the drug has been rolled out in a second-generation release and later, the New England Journal of Medicine published [...]